Artex 50mg
Generic: Artesunate
Category: Tablet
Manufacturer: Jayson Pharmaceuticals Ltd.
Allopathic
MFG. Licence No. Biological
003
MFG. Licence No. Non-Biological
082
Address
231, Tejgoan I/A, Dhaka.
Price: 130.2 ৳
Box
Tablet
Medicine Selling service is not available yet.
Alternative Brands & Related Medicines
Indications
Uses of Artex:
- Malaria
Falciparum malaria especially in quinidine-resistant patients
Adult: PO: 4 mg/kg once daily x3 days (with mefloquine)
Therapeutic Class
Anti-malarial drugs
Pharmacology
Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria.
Dosage and Administration
How to use Artesunate:
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Administration:
Antimalarial potentiating action seen with mefloquine, primaquine and tetracycline. Additive effect with chloroquine. Antagonistic effect with pyrimethamine and sulphonamides.
Adult Dose:
Hepatic or renal insufficiency. Pregnancy and lactation.
Lactation: unknown
Renal Dose:
Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria. Unclear, may inhibit DNA replication & transcription.
Interaction
Hypersensitivity.
Contraindications
Artesunate is contraindicated for patients with known hypersensitivity to Artemisinin and its derivatives or its inactive ingredients.
Side Effects
Common
- Headache
- Dizziness
- Weakness
- Loss of appetite
Pregnancy And Lactation
Pregnancy category is not classified. FDA has yet not classified the drug into a specific pregnancy catagory.
Precautions And Warnings
Precaution:
Malaria, Schistosomiasis
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
Anti-malarial drugs
Mode of Action
Artesunate is metabolized to the active DHA. the endoperoxide bridge of DHA reacts with heme, generating free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites during all erythrocytic stages. Reactions with these free radicals can also lead to alkylation of parasitic proteins such as a calcium adenosine triphosphatase and EXP1, a glutathione S-transferase.
Pregnancy Category
Generally well-tolerated, Cardiotoxicity (high doses), Neurotoxicity observed in animal studies, Drug induced fever, Skin rash
Samm Care