Pelocin Powder 10 gm/100 ml
Generic: Pefloxacin
Category: Powder
Manufacturer: Eon Pharmaceuticals Ltd.
Allopathic
MFG. Licence No. Biological
282
MFG. Licence No. Non-Biological
57
Address
217/5, Chandana, Joydebpur, Gazipur
Price: 151.02 ৳
100 gm Sachets
10 gm Sachets
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Alternative Brands & Related Medicines
Indications
Uses of Pelocin Powder:
- Bacterial infections
Susceptible infections, Gonococcal urethritis, Acute uncomplicated cystitis
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
Therapeutic Class
4-Quinolone preparations
Pharmacology
The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
Dosage and Administration
How to use
Pefloxacin:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Pefloxacin is to be taken with food.
Administration:
Should be taken with food. Take w/ meals.
Adult Dose:
Oral
Susceptible infections
Adult: 400 mg bid.
Acute uncomplicated cystitis in women; Gonococcal urethritis in men
Adult: 800 mg as single dose.
IV Influsion
Adult: 400 mg in 100 or 250 ml of 5% dextrose slow infusion over an hour bid.
Renal Dose:
Renal impairment: Dose reduction may be necessary.
Interaction
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.
Contraindications
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
Side Effects
Common
- Nausea
- Diarrhea
- Headache
- Dizziness
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.
Pregnancy And Lactation
Pregnancy category- not classified
Precautions And Warnings
Precaution:
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.
Storage Conditions
Store at room temperature. Keep away from excess heat and moisture.
Mode of Action
Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.
Samm Care