Fulvina 500 mg Tablet

    Fulvina 500 mg

    Generic: Griseofulvin

    Category: Tablet

    Manufacturer: Bikalpa Friends Pharmaceuticals Ltd.

    Indications

    Uses of Fulvina: - Fungal infections Dermatophytosis Severe liver disease; porphyria; monilial infection; SLE; pregnancy.

    Dosage and Administration

    How to use Griseofulvin: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Griseofulvin is to be taken with food. Administration: Should be taken with food. Take immediately after meals. Adult Dose: Oral Dermatophytosis Adult: 0.5-1 g daily in single or divided doses. Treatment duration: 2-8 wk (hair and skin infections); up to 6 mth (fingernail infections); >12 mth (toenail infections). Child Dose: Oral Dermatophytosis Child: PO 20–25 mg/kg q24h

    Interaction

    Antagonises oral anticoagulants and oral contraceptives. Decreased GI absorption with phenobarbital. Reduced plasma concentrations with enzyme inducers e.g. phenylbutazone and hypnotics. Potentially Fatal: Enhances effects of alcohol and causes disulfiram-like reaction.

    Contraindications

    Severe liver disease; porphyria; monilial infection; SLE; pregnancy.

    Side Effects

    Common - Headache - Skin rash - Nausea - Diarrhea - Dizziness Oral thrush; GI distress, taste perversion; dizziness, confusion, headache, depression, insomnia, fatigue; peripheral neuritis, photosensitivity; skin rashes, urticaria, erythema multiforme; leucopenia, proteinuria. Potentially Fatal: Hepatotoxicity; angioedema.

    Precautions And Warnings

    Precaution: Lactation; may impair ability to drive or operate machinery; avoid exposure to intense sunlight or artificial light. Regular monitoring of the renal, hepatic and blood tests should be done. Lactation: Excretion in milk unknown; avoid use because of potential tumorigenicity

    Mode of Action

    Griseofulvin is a fungistatic antibiotic that inhibits fungal cell division at metaphase and binds to human keratin making it resistant to fungal infections. It has activity against common dermatophytes including epidermophyton, Microsporum, or Trichophyton spp.
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