Dotarin 40 mg/2 ml

Uses of Dotarin: - Menstrual pain - Abdominal pain Gastrointestinal tract spasm, Irritable bowel syndrome, Dysmenorrhea, Biliary colics, Renal colics Severe renal/hepatic/cardiac dysfunction. Porphyria.

How to use Drotaverine Hydrochloride: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Drotaverine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral As an antispasmodic Adult: 1 to 2 tablets, 3 times daily. Injection: Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily. For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection. Child Dose: Oral As an antispasmodic Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily. 40 mg 1-2 times daily Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily. 20 mg 1-2 times daily

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

Severe renal/hepatic/cardiac dysfunction. Porphyria.

Common - Nausea - Vomiting - Dryness in mouth - Vertigo Vertigo, nausea, vomiting, dry mouth.

Precaution: Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.

Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.