Calcibo 1250 mg
Generic: Calcium carbonate
Category: Tablet
Manufacturer: Astra Biopharmaceuticals Ltd.
Allopathic
MFG. Licence No. Biological
238
MFG. Licence No. Non-Biological
462
Address
Gouripur, Ashulia, Savar Dhaka Ashulia Gouripur, Ashulia, Savar Dhaka
Price: 3.0 ৳
3 x 10 in Blister Pack
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Alternative Brands & Related Medicines
Indications
Heartburn, Indigestion, Calcium deficiency, Hypocalcaemia, Hyperphosphatemia, Calcium supplement, Stomach upset
Patients with Ca renal calculi or history of renal calculi; hypercalcaemia; hypophosphataemia. Patients with suspected digoxin toxicity.
Therapeutic Class
Minerals in bone formation, Specific mineral preparations
Pharmacology
Calcium carbonate reacts with gastric acid to produce a salt and water. For calcium carbonate the postulated chemical reaction is: CaCO3 + 2HCl = CaCl2 + H2O + CO2Two grams of calcium carbonate will readily bring 100 ml of hydrochloric acid to a pH above 6. The increase in gastric pH diminishes the activity of pepsin in the gastric secretion. Up to 30% of the oral calcium load may be absorbed.
Dosage and Administration
Administration:
May be taken with or without food. Take w/ meals for better absorption. Avoid taking w/ large amount of fibre-rich food.
Adult Dose:
Adult: PO Hyperacidity: Take 1-2 tab as needed, up to a max of 16 tab/day. May suck or chew tablets.
Hyperphosphataemia in chronic renal failure Initial: 2.5 g/day, up to 17 g/day in divided doses.
Renal Dose:
Renal impairment:
CrCl (ml/min)
<25 Dosage adjustments may be needed depending on serum calcium levels.
Interaction
Co-administration with thiazide diuretics or vit D may lead to milk-alkali syndrome and hypercalcaemia. Decreased absorption with corticosteroids. Decreases absorption of tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn and calcium-channel blockers. Enhances cardiac effects of digitalis glycosides and may precipitate digitalis intoxication.
Contraindications
Patients with Ca renal calculi or history of renal calculi; hypercalcaemia; hypophosphataemia. Patients with suspected digoxin toxicity.
Side Effects
Anorexia, nausea, vomiting, constipation, flatulence; hypercalcaemia; metabolic alkalosis; milk-alkali syndrome, tissue-calcification. Gastric hypersecretion and acid rebound (with prolonged use).
Pregnancy And Lactation
Calcium containing drugs have been widely used in pregnancy by way of oral calcium supplementation or antacid therapy. Calcium Carbonate can be used in lactating women too.
Precautions And Warnings
Precaution:
Renal impairment, hypoparathyroid disease, hypercalcaemia-associated diseases. Calcium absorption is impaired in achlorhydria; use an alternate salt and take with food. Caution when used in patients with a history of kidney stones.
Lactation: Safe; crosses the placenta; appears in breast milk
Storage Conditions
Store in a cool, dry place in controlled room temperature.
Mode of Action
Calcium carbonate can neutralise gastric acid rapidly and effectively. However, it may adversely activate Ca dependent processes, leading to secretion of gastric and hydrochloric acid. It can induce rebound acid secretion and, prolonged high doses may cause hypercalcemia, alkalosis and milk-alkali syndrome.
Pregnancy Category
Pregnancy category: C
Lactation: Safe; crosses the placenta; appears in breast milk
Samm Care