Alinix 500 mg
Generic: Nitazoxanide
Category: Tablet
Manufacturer: Healthcare Pharmacuticals Ltd.
Price: 10.0 ৳
1 x 10 in Blister Pack
30's pack
piece
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Alternative Brands & Related Medicines
Indications
Uses of Alinix:
- Diarrhea
- Worm infections
Giardiasis, Cryptosporidiosis
Hypersensitivity.
Therapeutic Class
Anti-diarrhoeal Antiprotozoal
Pharmacology
Nitazoxanide is a synthetic antiprotozoal agent for oral administration. The antiprotozoal activity of Nitazoxanide is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is essential for anaerobic energy metabolism of the protozoa. Nitazoxanide and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Dosage and Administration
How to use Nitazoxanide:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nitazoxanide is to be taken with food.
Administration:
Should be taken with food.
Adult Dose:
Oral
Giardiasis; Cryptosporidiosis
Adult: 500 mg every 12 hr for 3 days.
Child Dose:
Oral
Giardiasis; Cryptosporidiosis
Child:
1-3 yr: 100 mg(5 ml) every 12 hr;
4-11 yr: 200 mg(10ml) every 12 hr;
>12 yr: 500 mg every 12 hr.
All doses to be taken for 3 days.
Interaction
May possibly interact with highly protein-bound drugs e.g. warfarin.
Contraindications
Hypersensitivity.
Side Effects
Common
- Headache
- Nausea
- Fever
- Hair loss
- Vomiting
- Abnormal liver function tests
- Dizziness
- Abdominal pain
- Vertigo
1-10%
Headache (1%),Abdominal pain (8%),Diarrhea (2%),Nausea (3%),Chromaturia (2%),Vomiting (1%)
<1%
Increased ALT,Anorexia,Appetite increased,Creatinine increased,Diaphoresis,Dizziness,Eye discoloration (pale yellow),Fever,Flatulence,Infection,Malaise,Pruritus,Thinitis,Salivary glands enlarged,Urine discoloration
Pregnancy And Lactation
US FDA pregnancy category of Nitazoxanide is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nitazoxanide have been shown to be excreted in human milk. So, caution should be exercised when Nitazoxanide is administered during lactation.
Precautions And Warnings
Precaution:
Renal and hepatic impairment. Pregnancy and lactation. Children <1 yr.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Drug Classes
Anti-diarrhoeal Antiprotozoal
Mode of Action
Nitazoxanide is an antiprotozoal agent. Both nitazoxanide and its active metabolite (tizoxanide) interfere with the pyruvate:ferredoxin 2-oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic metabolism in susceptible organisms.
Pregnancy Category
US FDA pregnancy category of Nitazoxanide is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nitazoxanide have been shown to be excreted in human milk. So, caution should be exercised when Nitazoxanide is administered during lactation.
Samm Care